阿贝西利片英文说明书

Uses:

Abemaciclib is primarily used in the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer. It is usually prescribed in combination with an aromatase inhibitor for postmenopausal women or with fulvestrant for women and men with disease progression following endocrine therapy. Abemaciclib works by inhibiting CDK4 and CDK6, enzymes that promote cell cycle progression and tumor growth.

Dosage:

The recommended starting dosage of Abemaciclib is 150 mg taken orally twice daily, with or without food. The tablets should be swallowed whole and not crushed, chewed, or split. Dosage adjustments may be necessary based on individual tolerability and side effects. It is important to follow the instructions provided by the healthcare provider regarding the correct dosage and duration of treatment.

Potential Side Effects:

Like any medication, Abemaciclib may cause certain side effects. The most common side effects include diarrhea, fatigue, nausea, decreased appetite, abdominal pain, infections, and neutropenia (low white blood cell count). Diarrhea is the most frequently reported side effect and can be managed with anti-diarrheal medications and dietary adjustments. It is important to inform the healthcare provider about any side effects experienced during treatment.

Precautions:

Before starting Abemaciclib, it is necessary to inform the healthcare provider about any medical conditions or allergies. Abemaciclib may interact with other medications, including over-the-counter drugs and herbal supplements, so it is crucial to provide a complete list of all medications being taken. Abemaciclib may cause fetal harm when administered during pregnancy, so effective contraception is recommended during treatment and for at least three weeks after the last dose. Breastfeeding should be avoided during treatment with Abemaciclib.

It is important to attend regular follow-up appointments and laboratory tests as advised by the healthcare provider to monitor the effectiveness of the treatment and to detect any potential side effects. In case of a missed dose, it should be taken as soon as possible unless it is within six hours of the next scheduled dose, in which case the missed dose should be skipped. It is essential not to double the dose to make up for a missed one.

In conclusion, Abemaciclib is a medication used in the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. It works by inhibiting enzymes that promote cell cycle progression. While it may cause certain side effects, adherence to the prescribed dosage and precautions can help manage them effectively. It is essential to consult with a healthcare provider for specific instructions and guidance regarding the use of Abemaciclib.

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